Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	STAT3	HGNC:11364 (HGNC) 6774 (Entrez Gene) 102582 (OMIM) STAT3 (Alliance of Genome Resources)	Chr17 q21.2	Chr17:42313324-42388568 (-) GRCh38	Alzheimer's disease angiosarcoma Behcet's disease breast cancer colon adenocarcinoma Crohn's disease esophageal carcinoma head and neck squamous cell carcinoma hyper IgE recurrent infection syndrome 1 lymphoproliferative syndrome ovarian cancer prostate cancer prostate carcinoma psoriasis psoriatic arthritis rectum adenocarcinoma renal cell carcinoma rheumatoid arthritis squamous cell carcinoma type 2 diabetes mellitus ulcerative colitis	P40763 (UniProt | EBI) NM_001384984 (RefSeq)
mouse	Stat3	MGI:103038 (MGI) 20848 (Entrez Gene) Gene Tree Stat3 (Alliance of Genome Resources)	Chr11 63.82 cM	Chr11:100777632-100830447 (-) GRCm39	colorectal cancer hyper IgE recurrent infection syndrome 1 inflammatory bowel disease peripartum cardiomyopathy psoriasis	20848 (NCBI Gene Model) P42227 (UniProt | EBI) NM_213659 (RefSeq)
rat	Stat3	RGD:3772 (Rat Genome Database) 25125 (Entrez Gene) Stat3 (Alliance of Genome Resources)	Chr10 q31			P52631 (UniProt | EBI) NM_001430048 (RefSeq)
zebrafish	stat3	ZDB-GENE-980526-68 (Zebrafish Model Organism Database) 30767 (Entrez Gene) stat3 (Alliance of Genome Resources)	Chr3			NP_571554 (RefSeq) NM_131479 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.