Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	MTHFR	HGNC:7436 (HGNC) 4524 (Entrez Gene) 607093 (OMIM) MTHFR (Alliance of Genome Resources)	Chr1 p36.22	Chr1:11785723-11806455 (-) GRCh38	abdominal aortic aneurysm acute lymphoblastic leukemia acute myeloid leukemia alcoholic liver cirrhosis amyotrophic lateral sclerosis anemia angle-closure glaucoma ankylosing spondylitis aphthous stomatitis asthma atherosclerosis attention deficit hyperactivity disorder Budd-Chiari syndrome cardiovascular system disease carotid stenosis cataract cerebral infarction cervical cancer cholangiocarcinoma chronic kidney disease chronic myeloid leukemia clear cell renal cell carcinoma cleft lip coronary artery disease dextro-looped transposition of the great arteries diabetic retinopathy diffuse large B-cell lymphoma Down syndrome end stage renal disease eye disease factor VIII deficiency familial Mediterranean fever glomerulonephritis graft-versus-host disease Graves' disease hepatic veno-occlusive disease hepatitis B hepatocellular carcinoma hyperhomocysteinemia hypopituitarism inflammatory bowel disease ischemia kidney failure Kuhnt-Junius degeneration liver cirrhosis lung small cell carcinoma male infertility Meniere's disease metabolic dysfunction-associated steatotic liver disease migraine migraine with aura mitral valve disease multiple myeloma myeloid neoplasm myocardial infarction nephroblastoma nephrosclerosis neural tube defect non-arteritic anterior ischemic optic neuropathy open-angle glaucoma oral squamous cell carcinoma osteosarcoma pancreatic cancer peripheral artery disease portal vein thrombosis rectal benign neoplasm renal artery disease renal cell carcinoma retinal vein occlusion rheumatoid arthritis schizophrenia sickle cell anemia smallpox spina bifida squamous cell carcinoma steatotic liver disease tetralogy of Fallot thrombocytopenia thrombophilia thrombophilia due to thrombin defect transitional cell carcinoma type 1 diabetes mellitus type 2 diabetes mellitus urinary bladder cancer	P42898 (UniProt | EBI) NM_005957 (RefSeq)
mouse	Mthfr	MGI:106639 (MGI) 17769 (Entrez Gene) Gene Tree Mthfr (Alliance of Genome Resources)	Chr4 78.67 cM	Chr4:148123534-148144008 (+) GRCm39	neural tube defect	ENSMUSG00000029009 (Ensembl Gene Model) ENSMUSP00000069774 (Ensembl) ENSMUST00000069604 (Ensembl)
rat	Mthfr	RGD:1309952 (Rat Genome Database) 362657 (Entrez Gene) Mthfr (Alliance of Genome Resources)	Chr5 q36			NP_001413971 (RefSeq) NM_001427042 (RefSeq)
zebrafish	mthfr	ZDB-GENE-041111-215 (Zebrafish Model Organism Database) 567547 (Entrez Gene) mthfr (Alliance of Genome Resources)	Chr8			NP_001268769 (RefSeq) NM_001128255 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.