Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SMN1	HGNC:11117 (HGNC) 6606 (Entrez Gene) 600354 (OMIM) SMN1 (Alliance of Genome Resources)	Chr5 q13.2		adult spinal muscular atrophy intermediate spinal muscular atrophy juvenile spinal muscular atrophy spinal muscular atrophy Werdnig-Hoffmann disease	Q16637 (UniProt | EBI) NM_001297715 (RefSeq)
	SMN2	HGNC:11118 (HGNC) 6607 (Entrez Gene) 601627 (OMIM) SMN2 (Alliance of Genome Resources)	Chr5 q13.2		juvenile spinal muscular atrophy	Q16637 (UniProt | EBI) NM_017411 (RefSeq)
mouse	Smn1	MGI:109257 (MGI) 20595 (Entrez Gene) Gene Tree Smn1 (Alliance of Genome Resources)	Chr13 52.99 cM	Chr13:100261360-100274198 (+) GRCm39	juvenile spinal muscular atrophy Werdnig-Hoffmann disease	ENSMUSG00000021645 (Ensembl Gene Model) ENSMUSP00000022147 (Ensembl) ENSMUST00000022147 (Ensembl)
rat	Smn1	RGD:620755 (Rat Genome Database) 64301 (Entrez Gene) Smn1 (Alliance of Genome Resources)	Chr2 q12			O35876 (UniProt | EBI) NM_022509 (RefSeq)
zebrafish	smn1	ZDB-GENE-990715-16 (Zebrafish Model Organism Database) 30432 (Entrez Gene) smn1 (Alliance of Genome Resources)	Chr5			Q9W6S8 (UniProt | EBI) NM_131191 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.