Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	TWNK	HGNC:1160 (HGNC) 56652 (Entrez Gene) 606075 (OMIM) TWNK (Alliance of Genome Resources)	Chr10 q24.31	Chr10:100987367-100994403 (+) GRCh38	autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3 chronic progressive external ophthalmoplegia mitochondrial DNA depletion syndrome 7 Perrault syndrome	Q96RR1 (UniProt | EBI) NM_001163812 (RefSeq)
mouse	Twnk	MGI:2137410 (MGI) 226153 (Entrez Gene) Gene Tree Twnk (Alliance of Genome Resources)	Chr19 38.19 cM	Chr19:44994102-45001201 (+) GRCm39	Parkinson's disease	ENSMUSG00000025209 (Ensembl Gene Model) ENSMUSP00000026227 (Ensembl) ENSMUST00000026227 (Ensembl)
rat	Twnk	RGD:1307884 (Rat Genome Database) 309441 (Entrez Gene) Twnk (Alliance of Genome Resources)	Chr1 q54			NP_001101069 (RefSeq) NM_001107599 (RefSeq)
zebrafish	twnk	ZDB-GENE-030131-5569 (Zebrafish Model Organism Database) 100330448 (Entrez Gene) twnk (Alliance of Genome Resources)	Chr12			NP_001264527 (RefSeq) NM_001277598 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.