Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	MSH2	HGNC:7325 (HGNC) 4436 (Entrez Gene) 609309 (OMIM) MSH2 (Alliance of Genome Resources)	Chr2 p21-p16.3	Chr2:47403067-47709830 (+) GRCh38	breast cancer colon cancer colorectal cancer esophagus squamous cell carcinoma lung adenocarcinoma lung cancer lung non-small cell carcinoma Lynch syndrome Lynch syndrome 1 mismatch repair cancer syndrome Muir-Torre syndrome transitional cell carcinoma urinary bladder cancer	P43246 (UniProt | EBI) NM_001406647 (RefSeq)
mouse	Msh2	MGI:101816 (MGI) 17685 (Entrez Gene) Gene Tree Msh2 (Alliance of Genome Resources)	Chr17 57.87 cM	Chr17:87979960-88031141 (+) GRCm39	Lynch syndrome	17685 (NCBI Gene Model) P43247 (UniProt | EBI) NM_008628 (RefSeq)
rat	Msh2	RGD:620786 (Rat Genome Database) 81709 (Entrez Gene) Msh2 (Alliance of Genome Resources)	Chr6 q12			P54275 (UniProt | EBI) NM_031058 (RefSeq)
zebrafish	msh2	ZDB-GENE-040426-2932 (Zebrafish Model Organism Database) 406845 (Entrez Gene) msh2 (Alliance of Genome Resources)	Chr12			NP_998689 (RefSeq) NM_213524 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.