COMT Vertebrate HGNC

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Vertebrate Homology

Source

Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
- human
- mouse
- rat
- zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences select all deselect all Go
human	COMT	HGNC:2228 (HGNC) 1312 (Entrez Gene) 116790 (OMIM) COMT (Alliance of Genome Resources)	Chr22 q11.21	Chr22:19941371-19969975 (+) GRCh38	alcohol dependence alcohol use disorder amphetamine abuse attention deficit hyperactivity disorder autism spectrum disorder bipolar disorder breast cancer bulimia nervosa cannabis abuse cannabis dependence cocaine dependence cognitive disorder drug dependence endometrial cancer eumycotic mycetoma fibromyalgia heroin dependence hypertension intermittent explosive disorder leiomyoma lung cancer morphine dependence neonatal abstinence syndrome nicotine dependence obesity obsessive-compulsive disorder opiate dependence ovarian cancer pathological gambling prostate cancer psoriasis renal cell carcinoma schizophrenia uremia vitiligo withdrawal disorder	P21964 (UniProt \| EBI) NM_001135162 (RefSeq)
mouse	Comt	MGI:88470 (MGI) 12846 (Entrez Gene) Gene Tree Comt (Alliance of Genome Resources)	Chr16 11.4 cM	Chr16:18225636-18245602 (-) GRCm39	cognitive disorder pre-eclampsia	ENSMUSG00000000326 (Ensembl Gene Model) ENSMUSP00000000335 (Ensembl) ENSMUST00000000335 (Ensembl)
rat	Comt	RGD:2379 (Rat Genome Database) 24267 (Entrez Gene) Comt (Alliance of Genome Resources)	Chr11 q23			P22734 (UniProt \| EBI) NM_012531 (RefSeq)
zebrafish	comta	ZDB-GENE-050913-117 (Zebrafish Model Organism Database) 561372 (Entrez Gene) comta (Alliance of Genome Resources)	Chr8			F4ZGF2 (UniProt \| EBI) NM_001030157 (RefSeq)
zebrafish	comtb	ZDB-GENE-040724-164 (Zebrafish Model Organism Database) 565370 (Entrez Gene) comtb (Alliance of Genome Resources)	Chr11			A4IG53 (UniProt \| EBI) NM_001083843 (RefSeq)