Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	CAST	HGNC:1515 (HGNC) 831 (Entrez Gene) 114090 (OMIM) CAST (Alliance of Genome Resources)	Chr5 q15	Chr5:95961429-96779595 (+) GRCh38	congenital myasthenic syndrome 1A Parkinson's disease pemphigus PLACK syndrome psoriasis rheumatoid arthritis Sjogren's syndrome systemic lupus erythematosus vasculitis	P20810 (UniProt | EBI) NM_001750 (RefSeq)
mouse	Cast	MGI:1098236 (MGI) 12380 (Entrez Gene) Gene Tree Cast (Alliance of Genome Resources)	Chr13 40.52 cM	Chr13:74840487-74956929 (-) GRCm39		ENSMUSG00000021585 (Ensembl Gene Model) ENSMUSP00000152174 (Ensembl) ENSMUST00000223206 (Ensembl)
rat	Cast	RGD:2278 (Rat Genome Database) 25403 (Entrez Gene) Cast (Alliance of Genome Resources)	Chr2 q11			P27321 (UniProt | EBI) NM_001033716 (RefSeq)
zebrafish	cast	ZDB-GENE-050810-2 (Zebrafish Model Organism Database) 563084 (Entrez Gene) cast (Alliance of Genome Resources)	Chr21			NP_001124063 (RefSeq) NM_001130591 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.