Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	POLE	HGNC:9177 (HGNC) 5426 (Entrez Gene) 174762 (OMIM) POLE (Alliance of Genome Resources)	Chr12 q24.33	Chr12:132623753-132687376 (-) GRCh38	ascending colon cancer colorectal cancer endometrial cancer endometrial carcinoma lung cancer lung non-small cell carcinoma lung squamous cell carcinoma mismatch repair cancer syndrome	Q07864 (UniProt | EBI) NM_006231 (RefSeq)
mouse	Pole	MGI:1196391 (MGI) 18973 (Entrez Gene) Gene Tree Pole (Alliance of Genome Resources)	Chr5 53.45 cM	Chr5:110434185-110485319 (+) GRCm39		18973 (NCBI Gene Model) Q9WVF7 (UniProt | EBI) NM_011132 (RefSeq)
rat	Pole	RGD:1594540 (Rat Genome Database) 304573 (Entrez Gene) Pole (Alliance of Genome Resources)	Chr12 q16			NP_001100622 (RefSeq) NM_001107152 (RefSeq)
zebrafish	pole	ZDB-GENE-070705-557 (Zebrafish Model Organism Database) 553405 (Entrez Gene) pole (Alliance of Genome Resources)	Chr5			NP_001121995 (RefSeq) NM_001128523 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.