Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	L2HGDH	HGNC:20499 (HGNC) 79944 (Entrez Gene) 609584 (OMIM) L2HGDH (Alliance of Genome Resources)	Chr14 q21.3	Chr14:50237563-50312229 (-) GRCh38	2-hydroxyglutaric aciduria cerebellar ataxia hereditary spastic paraplegia L-2-hydroxyglutaric aciduria visual epilepsy	Q9H9P8 (UniProt | EBI) NM_001425218 (RefSeq)
mouse	L2hgdh	MGI:2384968 (MGI) 217666 (Entrez Gene) Gene Tree L2hgdh (Alliance of Genome Resources)	Chr12 28.94 cM	Chr12:69737210-69771648 (-) GRCm39	L-2-hydroxyglutaric aciduria	217666 (NCBI Gene Model) Q91YP0 (UniProt | EBI) NM_145443 (RefSeq)
rat	L2hgdh	RGD:1306250 (Rat Genome Database) 314196 (Entrez Gene) L2hgdh (Alliance of Genome Resources)	Chr6 q24			NP_001101498 (RefSeq) NM_001108028 (RefSeq)
zebrafish	l2hgdh	ZDB-GENE-090319-6 (Zebrafish Model Organism Database) 566872 (Entrez Gene) l2hgdh (Alliance of Genome Resources)	Chr13			NP_001139067 (RefSeq) NM_001145595 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.