Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	C3	HGNC:1318 (HGNC) 718 (Entrez Gene) 120700 (OMIM) C3 (Alliance of Genome Resources)	Chr19 p13.3	Chr19:6677704-6730562 (-) GRCh38	age related macular degeneration 7 age related macular degeneration 9 Alzheimer's disease asthma atypical hemolytic-uremic syndrome complement component 3 deficiency COVID-19 Kuhnt-Junius degeneration macular degeneration paroxysmal nocturnal hemoglobinuria sickle cell anemia silicosis systemic lupus erythematosus	P01024 (UniProt | EBI) NM_000064 (RefSeq)
mouse	C3	MGI:88227 (MGI) 12266 (Entrez Gene) Gene Tree C3 (Alliance of Genome Resources)	Chr17 29.72 cM	Chr17:57510970-57535136 (-) GRCm39	complement component 3 deficiency	ENSMUSG00000024164 (Ensembl Gene Model) ENSMUSP00000024988 (Ensembl) ENSMUST00000024988 (Ensembl)
rat	C3	RGD:2232 (Rat Genome Database) 24232 (Entrez Gene) C3 (Alliance of Genome Resources)	Chr9 q11			P01026 (UniProt | EBI) NM_016994 (RefSeq)
zebrafish	c3a.1	ZDB-GENE-990415-35 (Zebrafish Model Organism Database) 321046 (Entrez Gene) c3a.1 (Alliance of Genome Resources)	Chr1			NP_571317 (RefSeq) NM_131242 (RefSeq)
	c3a.2	ZDB-GENE-990415-36 (Zebrafish Model Organism Database) 30491 (Entrez Gene) c3a.2 (Alliance of Genome Resources)	Chr1			NP_571318 (RefSeq) NM_131243 (RefSeq)
	c3a.3	ZDB-GENE-990415-37 (Zebrafish Model Organism Database) 565074 (Entrez Gene) c3a.3 (Alliance of Genome Resources)	Chr1			NP_001032313 (RefSeq) NM_001037236 (RefSeq)
	c3a.4	ZDB-GENE-140822-3 (Zebrafish Model Organism Database) 100331428 (Entrez Gene) c3a.4 (Alliance of Genome Resources)	Chr1			XP_002660623 (RefSeq)
	c3a.6	ZDB-GENE-041212-2 (Zebrafish Model Organism Database) 494039 (Entrez Gene) c3a.6 (Alliance of Genome Resources)	Chr1			NP_001008582 (RefSeq) NM_001008582 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.