Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	TBX5	HGNC:11604 (HGNC) 6910 (Entrez Gene) 601620 (OMIM) TBX5 (Alliance of Genome Resources)	Chr12 q24.21	Chr12:114353911-114408442 (-) GRCh38	Holt-Oram syndrome	Q99593 (UniProt | EBI) NM_080717 (RefSeq)
mouse	Tbx5	MGI:102541 (MGI) 21388 (Entrez Gene) Gene Tree Tbx5 (Alliance of Genome Resources)	Chr5 60.42 cM	Chr5:119970733-120023284 (+) GRCm39	Holt-Oram syndrome	ENSMUSG00000018263 (Ensembl Gene Model) ENSMUSP00000018407 (Ensembl) ENSMUST00000018407 (Ensembl)
rat	Tbx5	RGD:1305702 (Rat Genome Database) 304514 (Entrez Gene) Tbx5 (Alliance of Genome Resources)	Chr12 q16			Q5I2P1 (UniProt | EBI) NM_001009964 (RefSeq)
zebrafish	tbx5a	ZDB-GENE-991124-7 (Zebrafish Model Organism Database) 30071 (Entrez Gene) tbx5a (Alliance of Genome Resources)	Chr5			Q9IAK8 (UniProt | EBI) NM_130915 (RefSeq)
	tbx5b	ZDB-GENE-060601-2 (Zebrafish Model Organism Database) 100004161 (Entrez Gene) tbx5b (Alliance of Genome Resources)	Chr5			NP_001185700 (RefSeq) NM_001198771 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.