Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	NOTCH3	HGNC:7883 (HGNC) 4854 (Entrez Gene) 600276 (OMIM) NOTCH3 (Alliance of Genome Resources)	Chr19 p13.12	Chr19:15159038-15200995 (-) GRCh38	CADASIL 1 infantile myofibromatosis lateral meningocele syndrome	Q9UM47 (UniProt | EBI) NM_000435 (RefSeq)
mouse	Notch3	MGI:99460 (MGI) 18131 (Entrez Gene) Gene Tree Notch3 (Alliance of Genome Resources)	Chr17 17.37 cM	Chr17:32339794-32385826 (-) GRCm39	acute lymphoblastic leukemia CADASIL 1	ENSMUSG00000038146 (Ensembl Gene Model) ENSMUSP00000085016 (Ensembl) ENSMUST00000087723 (Ensembl)
rat	Notch3	RGD:620761 (Rat Genome Database) 56761 (Entrez Gene) Notch3 (Alliance of Genome Resources)	Chr7 q11			Q9R172 (UniProt | EBI) NM_020087 (RefSeq)
zebrafish	notch3	ZDB-GENE-000329-5 (Zebrafish Model Organism Database) 58066 (Entrez Gene) notch3 (Alliance of Genome Resources)	Chr3			NP_571624 (RefSeq) NM_131549 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.