Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	CASP3	HGNC:1504 (HGNC) 836 (Entrez Gene) 600636 (OMIM) CASP3 (Alliance of Genome Resources)	Chr4 q35.1	Chr4:184627696-184650062 (-) GRCh38	colon cancer lung non-small cell carcinoma Parkinson's disease stomach cancer	P42574 (UniProt | EBI) NM_001354777 (RefSeq)
mouse	Casp3	MGI:107739 (MGI) 12367 (Entrez Gene) Gene Tree Casp3 (Alliance of Genome Resources)	Chr8 26.39 cM	Chr8:47070326-47092724 (+) GRCm39		ENSMUSG00000031628 (Ensembl Gene Model) ENSMUSP00000147767 (Ensembl) ENSMUST00000211115 (Ensembl)
rat	Casp3	RGD:2275 (Rat Genome Database) 25402 (Entrez Gene) Casp3 (Alliance of Genome Resources)	Chr16 q11			P55213 (UniProt | EBI) NM_012922 (RefSeq)
zebrafish	casp3a	ZDB-GENE-011210-1 (Zebrafish Model Organism Database) 140621 (Entrez Gene) casp3a (Alliance of Genome Resources)	Chr1			NP_571952 (RefSeq) NM_131877 (RefSeq)
	casp3b	ZDB-GENE-070607-1 (Zebrafish Model Organism Database) 566604 (Entrez Gene) casp3b (Alliance of Genome Resources)	Chr14			NP_001041531 (RefSeq) NM_001048066 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.