Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	INS	HGNC:6081 (HGNC) 3630 (Entrez Gene) 176730 (OMIM) INS (Alliance of Genome Resources)	Chr11 p15.5	Chr11:2159779-2161221 (-) GRCh38	diabetes mellitus diabetic retinopathy hyperinsulinism insulinoma maturity-onset diabetes of the young type 10 pancreatic cancer permanent neonatal diabetes mellitus type 1 diabetes mellitus type 1 diabetes mellitus 2 type 2 diabetes mellitus	P01308 (UniProt | EBI) NM_000207 (RefSeq)
mouse	Ins2	MGI:96573 (MGI) 16334 (Entrez Gene) Gene Tree Ins2 (Alliance of Genome Resources)	Chr7 88.0 cM	Chr7:142232393-142233463 (-) GRCm39	maturity-onset diabetes of the young neonatal diabetes permanent neonatal diabetes mellitus type 1 diabetes mellitus type 2 diabetes mellitus	16334 (NCBI Gene Model) P01326 (UniProt | EBI) NM_001185084 (RefSeq)
rat	Ins2	RGD:2916 (Rat Genome Database) 24506 (Entrez Gene) Ins2 (Alliance of Genome Resources)	Chr1 q41			P01323 (UniProt | EBI) NM_019130 (RefSeq)
zebrafish	ins	ZDB-GENE-980526-110 (Zebrafish Model Organism Database) 30262 (Entrez Gene) ins (Alliance of Genome Resources)	Chr5			O73727 (UniProt | EBI) NM_131056 (RefSeq)
	insb	ZDB-GENE-040113-2 (Zebrafish Model Organism Database) 566735 (Entrez Gene) insb (Alliance of Genome Resources)	Chr14			NP_001034153 (RefSeq) NM_001039064 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.