Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	HMGCR	HGNC:5006 (HGNC) 3156 (Entrez Gene) 142910 (OMIM) HMGCR (Alliance of Genome Resources)	Chr5 q13.3	Chr5:75336329-75364001 (+) GRCh38	Alzheimer's disease asthma attention deficit hyperactivity disorder autosomal recessive limb-girdle muscular dystrophy coronary artery disease dementia diabetes mellitus intermediate coronary syndrome muscular disease Parkinson's disease type 2 diabetes mellitus	P04035 (UniProt | EBI) NM_001364187 (RefSeq)
mouse	Hmgcr	MGI:96159 (MGI) 15357 (Entrez Gene) Gene Tree Hmgcr (Alliance of Genome Resources)	Chr13 50.65 cM	Chr13:96785475-96807444 (-) GRCm39		ENSMUSG00000021670 (Ensembl Gene Model) ENSMUSP00000022176 (Ensembl) ENSMUST00000022176 (Ensembl)
rat	Hmgcr	RGD:2803 (Rat Genome Database) 25675 (Entrez Gene) Hmgcr (Alliance of Genome Resources)	Chr2 q12			P51639 (UniProt | EBI) NM_013134 (RefSeq)
zebrafish	hmgcra	ZDB-GENE-040401-2 (Zebrafish Model Organism Database) 559054 (Entrez Gene) hmgcra (Alliance of Genome Resources)	Chr5			NP_001073446 (RefSeq) NM_001126459 (RefSeq)
	hmgcrb	ZDB-GENE-051108-1 (Zebrafish Model Organism Database) 541479 (Entrez Gene) hmgcrb (Alliance of Genome Resources)	Chr21			NP_001014314 (RefSeq) NM_001014292 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.