Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	BRCA2	HGNC:1101 (HGNC) 675 (Entrez Gene) 600185 (OMIM) BRCA2 (Alliance of Genome Resources)	Chr13 q13.1	Chr13:32315086-32400268 (+) GRCh38	breast cancer ductal carcinoma in situ endometrial cancer endometrial serous adenocarcinoma esophagus squamous cell carcinoma Fanconi anemia Fanconi anemia complementation group D1 hereditary breast ovarian cancer syndrome high grade glioma medulloblastoma melanoma nephroblastoma ovarian cancer pancreatic cancer prostate cancer skin melanoma uveal melanoma	P51587 (UniProt | EBI) NM_000059 (RefSeq)
mouse	Brca2	MGI:109337 (MGI) 12190 (Entrez Gene) Gene Tree Brca2 (Alliance of Genome Resources)	Chr5 89.52 cM	Chr5:150446095-150493794 (+) GRCm39	breast cancer Fanconi anemia complementation group D1	ENSMUSG00000041147 (Ensembl Gene Model) ENSMUSP00000038576 (Ensembl) ENSMUST00000044620 (Ensembl)
rat	Brca2	RGD:2219 (Rat Genome Database) 360254 (Entrez Gene) Brca2 (Alliance of Genome Resources)	Chr12 p12			O35923 (UniProt | EBI) NM_031542 (RefSeq)
zebrafish	brca2	ZDB-GENE-060510-3 (Zebrafish Model Organism Database) 566758 (Entrez Gene) brca2 (Alliance of Genome Resources)	Chr15			NP_001103864 (RefSeq) NM_001110394 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.