Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	CTLA4	HGNC:2505 (HGNC) 1493 (Entrez Gene) 123890 (OMIM) CTLA4 (Alliance of Genome Resources)	Chr2 q33.2	Chr2:203853888-203873965 (+) GRCh38	acute myeloid leukemia alopecia areata anti-basement membrane glomerulonephritis asthma atopic dermatitis autoimmune hemolytic anemia autoimmune hepatitis autoimmune thyroiditis basal cell carcinoma Behcet's disease breast cancer celiac disease chronic obstructive pulmonary disease end stage renal disease graft-versus-host disease granulomatosis with polyangiitis Graves' disease Graves ophthalmopathy hepatitis B hepatocellular carcinoma immunoglobulin alpha deficiency iridocyclitis kidney disease latent autoimmune diabetes in adults lupus nephritis melanoma monoclonal gammopathy of uncertain significance multiple myeloma multiple sclerosis myocardial infarction non-Hodgkin lymphoma primary biliary cholangitis primary immunodeficiency disease psoriasis renal cell carcinoma sarcoidosis Sjogren's syndrome squamous cell carcinoma systemic lupus erythematosus type 1 diabetes mellitus type 1 diabetes mellitus 12 urinary schistosomiasis vitiligo	P16410 (UniProt | EBI) NM_001037631 (RefSeq)
mouse	Ctla4	MGI:88556 (MGI) 12477 (Entrez Gene) Gene Tree Ctla4 (Alliance of Genome Resources)	Chr1 30.58 cM	Chr1:60948184-60954991 (+) GRCm39		12477 (NCBI Gene Model) P09793 (UniProt | EBI) NM_009843 (RefSeq)
rat	Ctla4	RGD:61975 (Rat Genome Database) 63835 (Entrez Gene) Ctla4 (Alliance of Genome Resources)	Chr9 q32			NP_113862 (RefSeq) NM_031674 (RefSeq)
zebrafish	cd28	ZDB-GENE-070912-128 (Zebrafish Model Organism Database) 101886406 (Entrez Gene) cd28 (Alliance of Genome Resources)	Chr9			XP_068079618 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.