Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	AIRE	HGNC:360 (HGNC) 326 (Entrez Gene) 607358 (OMIM) AIRE (Alliance of Genome Resources)	Chr21 q22.3	Chr21:44285838-44298648 (+) GRCh38	autoimmune polyendocrine syndrome autoimmune polyendocrine syndrome type 1	O43918 (UniProt | EBI) NM_000659 (RefSeq)
mouse	Aire	MGI:1338803 (MGI) 11634 (Entrez Gene) Gene Tree Aire (Alliance of Genome Resources)	Chr10 39.72 cM	Chr10:77865856-77879444 (-) GRCm39	autoimmune polyendocrine syndrome type 1 Guillain-Barre syndrome Sjogren's syndrome	11634 (NCBI Gene Model) Q9Z0E3 (UniProt | EBI) NR_073358 (RefSeq)
rat	Aire	RGD:1311139 (Rat Genome Database) 294328 (Entrez Gene) Aire (Alliance of Genome Resources)	Chr20 p12			NP_001099849 (RefSeq) NM_001106379 (RefSeq)
zebrafish	aire	ZDB-GENE-071008-4 (Zebrafish Model Organism Database) 100007662 (Entrez Gene) aire (Alliance of Genome Resources)	Chr2			NP_001103484 (RefSeq) NM_001110014 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.