Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	IDH2	HGNC:5383 (HGNC) 3418 (Entrez Gene) 147650 (OMIM) IDH2 (Alliance of Genome Resources)	Chr15 q26.1	Chr15:90083045-90102477 (-) GRCh38	acute myeloid leukemia D-2-hydroxyglutaric aciduria 2 esophagus squamous cell carcinoma hepatocellular clear cell carcinoma intrahepatic cholangiocarcinoma lung cancer lung non-small cell carcinoma lung squamous cell carcinoma	P48735 (UniProt | EBI) NM_001289910 (RefSeq)
mouse	Idh2	MGI:96414 (MGI) 269951 (Entrez Gene) Gene Tree Idh2 (Alliance of Genome Resources)	Chr7 45.43 cM	Chr7:79744594-79765140 (-) GRCm39	bone remodeling disease	ENSMUSG00000030541 (Ensembl Gene Model) ENSMUSP00000103007 (Ensembl) ENSMUST00000107384 (Ensembl)
rat	Idh2	RGD:1597139 (Rat Genome Database) 361596 (Entrez Gene) Idh2 (Alliance of Genome Resources)	Chr1 q31			P56574 (UniProt | EBI) NM_001014161 (RefSeq)
zebrafish	idh2	ZDB-GENE-031118-95 (Zebrafish Model Organism Database) 386951 (Entrez Gene) idh2 (Alliance of Genome Resources)	Chr18			NP_955858 (RefSeq) NM_199564 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.