Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	RPE65	HGNC:10294 (HGNC) 6121 (Entrez Gene) 180069 (OMIM) RPE65 (Alliance of Genome Resources)	Chr1 p31.3	Chr1:68428822-68451103 (-) GRCh38	Leber congenital amaurosis 2 retinitis pigmentosa retinitis pigmentosa 20 retinitis pigmentosa 87	Q16518 (UniProt | EBI) NM_001406860 (RefSeq)
mouse	Rpe65	MGI:98001 (MGI) 19892 (Entrez Gene) Gene Tree Rpe65 (Alliance of Genome Resources)	Chr3 82.52 cM	Chr3:159304812-159330958 (+) GRCm39	Leber congenital amaurosis 2 retinitis pigmentosa 20	ENSMUSG00000028174 (Ensembl Gene Model) ENSMUSP00000029824 (Ensembl) ENSMUST00000029824 (Ensembl)
rat	Rpe65	RGD:621396 (Rat Genome Database) 89826 (Entrez Gene) Rpe65 (Alliance of Genome Resources)	Chr2 q45			O70276 (UniProt | EBI) NM_053562 (RefSeq)
zebrafish	rpe65a	ZDB-GENE-040426-1717 (Zebrafish Model Organism Database) 393724 (Entrez Gene) rpe65a (Alliance of Genome Resources)	Chr2			Q6PBW5 (UniProt | EBI) NM_200751 (RefSeq)
	rpe65b	ZDB-GENE-050410-16 (Zebrafish Model Organism Database) 100002865 (Entrez Gene) rpe65b (Alliance of Genome Resources)	Chr8			A9C3R9 (UniProt | EBI) NM_001089433 (RefSeq)
	rpe65c	ZDB-GENE-081104-505 (Zebrafish Model Organism Database) 100004076 (Entrez Gene) rpe65c (Alliance of Genome Resources)	Chr8			A9C3R8 (UniProt | EBI) NM_001113653 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.