Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SMAD3	HGNC:6769 (HGNC) 4088 (Entrez Gene) 603109 (OMIM) SMAD3 (Alliance of Genome Resources)	Chr15 q22.33	Chr15:67063763-67195173 (+) GRCh38	Loeys-Dietz syndrome 3 Lynch syndrome pancreatic cancer	P84022 (UniProt | EBI) NM_005902 (RefSeq)
mouse	Smad3	MGI:1201674 (MGI) 17127 (Entrez Gene) Gene Tree Smad3 (Alliance of Genome Resources)	Chr9 34.22 cM	Chr9:63554049-63665276 (-) GRCm39	osteoarthritis	ENSMUSG00000032402 (Ensembl Gene Model) ENSMUSP00000034973 (Ensembl) ENSMUST00000034973 (Ensembl)
rat	Smad3	RGD:3032 (Rat Genome Database) 25631 (Entrez Gene) Smad3 (Alliance of Genome Resources)	Chr8 q24			P84025 (UniProt | EBI) NM_013095 (RefSeq)
zebrafish	smad3a	ZDB-GENE-000509-3 (Zebrafish Model Organism Database) 58092 (Entrez Gene) smad3a (Alliance of Genome Resources)	Chr7			NP_571646 (RefSeq) NM_131571 (RefSeq)
	smad3b	ZDB-GENE-030128-4 (Zebrafish Model Organism Database) 326283 (Entrez Gene) smad3b (Alliance of Genome Resources)	Chr18			NP_778258 (RefSeq) NM_175083 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.