Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	APP	HGNC:620 (HGNC) 351 (Entrez Gene) 104760 (OMIM) APP (Alliance of Genome Resources)	Chr21 q21.3	Chr21:25880535-26171128 (-) GRCh38	Alzheimer's disease Alzheimer's disease 1 APP-related cerebral amyloid angiopathy cognitive disorder traumatic brain injury visual epilepsy	P05067 (UniProt | EBI) NM_201414 (RefSeq)
mouse	App	MGI:88059 (MGI) 11820 (Entrez Gene) Gene Tree App (Alliance of Genome Resources)	Chr16 46.92 cM	Chr16:84751236-84972187 (-) GRCm39	Alzheimer's disease	11820 (NCBI Gene Model) P12023 (UniProt | EBI) NM_001198823 (RefSeq)
rat	App	RGD:2139 (Rat Genome Database) 54226 (Entrez Gene) App (Alliance of Genome Resources)	Chr11 q11			P08592 (UniProt | EBI) NM_019288 (RefSeq)
zebrafish	appa	ZDB-GENE-000616-13 (Zebrafish Model Organism Database) 58083 (Entrez Gene) appa (Alliance of Genome Resources)	Chr1			NP_571639 (RefSeq) NM_131564 (RefSeq)
	appb	ZDB-GENE-020220-1 (Zebrafish Model Organism Database) 170846 (Entrez Gene) appb (Alliance of Genome Resources)	Chr9			NP_690842 (RefSeq) NM_152886 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.