Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	GDNF	HGNC:4232 (HGNC) 2668 (Entrez Gene) 600837 (OMIM) GDNF (Alliance of Genome Resources)	Chr5 p13.2	Chr5:37812677-37840041 (-) GRCh38	anxiety disorder depressive disorder epilepsy glomerulonephritis heroin dependence Hirschsprung's disease Parkinsonism	P39905 (UniProt | EBI) NM_001190468 (RefSeq)
mouse	Gdnf	MGI:107430 (MGI) 14573 (Entrez Gene) Gene Tree Gdnf (Alliance of Genome Resources)	Chr15 3.8 cM	Chr15:7840327-7867056 (+) GRCm39	Hirschsprung's disease	ENSMUSG00000022144 (Ensembl Gene Model) ENSMUSP00000022744 (Ensembl) ENSMUST00000022744 (Ensembl)
rat	Gdnf	RGD:2677 (Rat Genome Database) 25453 (Entrez Gene) Gdnf (Alliance of Genome Resources)	Chr2 q16			Q07731 (UniProt | EBI) NM_019139 (RefSeq)
zebrafish	gdnfa	ZDB-GENE-010226-1 (Zebrafish Model Organism Database) 79379 (Entrez Gene) gdnfa (Alliance of Genome Resources)	Chr10			Q98TU0 (UniProt | EBI) NM_131732 (RefSeq)
	gdnfb	ZDB-GENE-110609-2 (Zebrafish Model Organism Database) 101885082 (Entrez Gene) gdnfb (Alliance of Genome Resources)	Chr5			XP_009299466 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.