Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	CACNA1C	HGNC:1390 (HGNC) 775 (Entrez Gene) 114205 (OMIM) CACNA1C (Alliance of Genome Resources)	Chr12 p13.33	Chr12:1970772-2697950 (+) GRCh38	Brugada syndrome 3 long QT syndrome 8 neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures Timothy syndrome	Q13936 (UniProt | EBI) NM_199460 (RefSeq)
mouse	Cacna1c	MGI:103013 (MGI) 12288 (Entrez Gene) Gene Tree Cacna1c (Alliance of Genome Resources)	Chr6 55.86 cM	Chr6:118564201-119173851 (-) GRCm39	Timothy syndrome	ENSMUSG00000051331 (Ensembl Gene Model) ENSMUSP00000108413 (Ensembl) ENSMUST00000112793 (Ensembl)
rat	Cacna1c	RGD:2245 (Rat Genome Database) 24239 (Entrez Gene) Cacna1c (Alliance of Genome Resources)	Chr4 q42			P22002 (UniProt | EBI) NM_012517 (RefSeq)
zebrafish	cacna1c	ZDB-GENE-020129-1 (Zebrafish Model Organism Database) 170581 (Entrez Gene) cacna1c (Alliance of Genome Resources)	Chr4			NP_571975 (RefSeq) NM_131900 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.