Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	ACE	HGNC:2707 (HGNC) 1636 (Entrez Gene) 106180 (OMIM) ACE (Alliance of Genome Resources)	Chr17 q23.3	Chr17:63477061-63498380 (+) GRCh38	allergic disease anemia ankylosing spondylitis aspiration pneumonia asthma atrial fibrillation Behcet's disease breast cancer cerebral infarction chronic obstructive pulmonary disease coronary artery disease Coronavirus infectious disease COVID-19 diabetic retinopathy diastolic heart failure end stage renal disease Fabry disease familial Mediterranean fever gallbladder adenocarcinoma heart valve disease Henoch-Schoenlein purpura hepatitis A hepatocellular carcinoma hypertension IgA glomerulonephritis leukemia liver cirrhosis lung cancer mitral valve disease mitral valve prolapse multiple myeloma myocardial infarction nephritis non-arteritic anterior ischemic optic neuropathy obstructive sleep apnea pneumonia polycythemia pre-eclampsia proteinuria sarcoidosis stomach cancer subacute sclerosing panencephalitis toxic shock syndrome type 1 diabetes mellitus type 2 diabetes mellitus	P12821 (UniProt | EBI) NM_001382702 (RefSeq)
mouse	Ace	MGI:87874 (MGI) 11421 (Entrez Gene) Gene Tree Ace (Alliance of Genome Resources)	Chr11 68.84 cM	Chr11:105858774-105880790 (+) GRCm39		11421 (NCBI Gene Model) P09470 (UniProt | EBI) NM_001281819 (RefSeq)
rat	Ace	RGD:2493 (Rat Genome Database) 24310 (Entrez Gene) Ace (Alliance of Genome Resources)	Chr10 q32.1			P47820 (UniProt | EBI) NM_012544 (RefSeq)
zebrafish	ace	ZDB-GENE-030131-1826 (Zebrafish Model Organism Database) 565980 (Entrez Gene) ace (Alliance of Genome Resources)	Chr12			XP_694336 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.