Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	NPC1	HGNC:7897 (HGNC) 4864 (Entrez Gene) 607623 (OMIM) NPC1 (Alliance of Genome Resources)	Chr18 q11.2	Chr18:23506184-23586506 (-) GRCh38	Niemann-Pick disease type C1	O15118 (UniProt | EBI) NM_000271 (RefSeq)
mouse	Npc1	MGI:1097712 (MGI) 18145 (Entrez Gene) Gene Tree Npc1 (Alliance of Genome Resources)	Chr18 6.15 cM	Chr18:12322749-12369457 (-) GRCm39	Niemann-Pick disease Niemann-Pick disease type C1	ENSMUSG00000024413 (Ensembl Gene Model) ENSMUSP00000025279 (Ensembl) ENSMUST00000025279 (Ensembl)
rat	Npc1	RGD:628693 (Rat Genome Database) 266732 (Entrez Gene) Npc1 (Alliance of Genome Resources)	Chr18 p13			NP_705888 (RefSeq) NM_153624 (RefSeq)
zebrafish	npc1	ZDB-GENE-030131-3161 (Zebrafish Model Organism Database) 553330 (Entrez Gene) npc1 (Alliance of Genome Resources)	Chr2			NP_001230804 (RefSeq) NM_001243875 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.