PTEN Vertebrate HGNC

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Vertebrate Homology

Source

Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
- human
- mouse
- rat
- zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences select all deselect all Go
human	PTEN	HGNC:9588 (HGNC) 5728 (Entrez Gene) 601728 (OMIM) PTEN (Alliance of Genome Resources)	Chr10 q23.31	Chr10:87862638-87971930 (+) GRCh38	Bannayan-Riley-Ruvalcaba syndrome breast cancer Epstein-Barr virus infectious disease esophageal cancer familial meningioma high grade glioma lung non-small cell carcinoma macrocephaly-autism syndrome ovarian cancer peripheral nervous system neoplasm prostate cancer PTEN hamartoma tumor syndrome sporadic breast cancer urinary bladder cancer	P60484 (UniProt \| EBI) NM_000314 (RefSeq)
mouse	Pten	MGI:109583 (MGI) 19211 (Entrez Gene) Gene Tree Pten (Alliance of Genome Resources)	Chr19 28.14 cM	Chr19:32734977-32803560 (+) GRCm39	acute lymphoblastic leukemia autism spectrum disorder Bannayan-Riley-Ruvalcaba syndrome brain disease Cowden syndrome endometrial cancer follicular thyroid carcinoma hepatocellular carcinoma intestinal pseudo-obstruction macrocephaly-autism syndrome persistent fetal circulation syndrome prostate cancer steatotic liver disease urinary bladder cancer	19211 (NCBI Gene Model) O08586 (UniProt \| EBI) NM_008960 (RefSeq)
rat	Pten	RGD:61995 (Rat Genome Database) 50557 (Entrez Gene) Pten (Alliance of Genome Resources)	Chr1 q52			O54857 (UniProt \| EBI) NM_031606 (RefSeq)
zebrafish	ptena	ZDB-GENE-030131-3776 (Zebrafish Model Organism Database) 794088 (Entrez Gene) ptena (Alliance of Genome Resources)	Chr17			NP_957002 (RefSeq) NM_200708 (RefSeq)
zebrafish	ptenb	ZDB-GENE-030616-47 (Zebrafish Model Organism Database) 368415 (Entrez Gene) ptenb (Alliance of Genome Resources)	Chr12			NP_001410617 (RefSeq) NM_001423688 (RefSeq)