Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	IRS1	HGNC:6125 (HGNC) 3667 (Entrez Gene) 147545 (OMIM) IRS1 (Alliance of Genome Resources)	Chr2 q36.3	Chr2:226731312-226799820 (-) GRCh38	Alzheimer's disease coronary artery disease type 2 diabetes mellitus uterine fibroid	P35568 (UniProt | EBI) NM_005544 (RefSeq)
mouse	Irs1	MGI:99454 (MGI) 16367 (Entrez Gene) Gene Tree Irs1 (Alliance of Genome Resources)	Chr1 42.0 cM	Chr1:82210822-82269137 (-) GRCm39	type 2 diabetes mellitus	ENSMUSG00000055980 (Ensembl Gene Model) ENSMUSP00000063795 (Ensembl) ENSMUST00000069799 (Ensembl)
rat	Irs1	RGD:2922 (Rat Genome Database) 25467 (Entrez Gene) Irs1 (Alliance of Genome Resources)	Chr9 q34			P35570 (UniProt | EBI) NM_012969 (RefSeq)
zebrafish	irs1	ZDB-GENE-030131-872 (Zebrafish Model Organism Database) 559281 (Entrez Gene) irs1 (Alliance of Genome Resources)	Chr15			XP_687702 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.