Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	HLA-DQA1	HGNC:4942 (HGNC) 3117 (Entrez Gene) 146880 (OMIM) HLA-DQA1 (Alliance of Genome Resources)	Chr6 p21.32	Chr6:32628179-32655272 (+) GRCh38	abdominal aortic aneurysm achalasia acute lymphoblastic leukemia allergic disease alopecia areata ankylosing spondylitis antiphospholipid syndrome aplastic anemia arthritis aspirin-induced respiratory disease asthma autoimmune disease autoimmune polyendocrine syndrome autoimmune polyendocrine syndrome type 2 autoimmune thyroiditis brain infarction breast cancer celiac disease choreatic disease chronic fatigue syndrome chronic myeloid leukemia colon carcinoma congenital toxoplasmosis diffuse scleroderma dilated cardiomyopathy 1H extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue factor VIII deficiency gastric adenocarcinoma glucose intolerance Graves' disease Henoch-Schoenlein purpura hepatitis B hepatitis C hepatocellular carcinoma human immunodeficiency virus infectious disease hypertension juvenile rheumatoid arthritis lepromatous leprosy liver cirrhosis lupus nephritis marginal zone lymphoma melanoma membranous glomerulonephritis multiple sclerosis myasthenia gravis myositis narcolepsy onchocerciasis paroxysmal nocturnal hemoglobinuria pemphigus primary biliary cholangitis psoriasis rheumatic fever rheumatic heart disease rheumatoid arthritis rhinitis rhinoscleroma Sjogren's syndrome stomach cancer systemic scleroderma thrombophilia type 1 diabetes mellitus type 2 diabetes mellitus visceral leishmaniasis vitiligo Vogt-Koyanagi-Harada disease	P01909 (UniProt | EBI) NM_002122 (RefSeq)
	HLA-DQA2	HGNC:4943 (HGNC) 3118 (Entrez Gene) 613503 (OMIM) HLA-DQA2 (Alliance of Genome Resources)	Chr6 p21.32	Chr6:32741391-32747198 (+) GRCh38	asthma	P01906 (UniProt | EBI) NM_020056 (RefSeq)
mouse	H2-Aa	MGI:95895 (MGI) 14960 (Entrez Gene) Gene Tree H2-Aa (Alliance of Genome Resources)	Chr17 17.98 cM	Chr17:34501718-34506797 (-) GRCm39		14960 (NCBI Gene Model) P14434 (UniProt | EBI) NM_010378 (RefSeq)
rat	RT1-Ba	RGD:1595867 (Rat Genome Database) 309621 (Entrez Gene) RT1-Ba (Alliance of Genome Resources)	Chr20 p12			P20037 (UniProt | EBI) NM_001008831 (RefSeq)
zebrafish	mhc2d8.35a1	ZDB-GENE-131121-38 (Zebrafish Model Organism Database) 795595 (Entrez Gene) mhc2d8.35a1 (Alliance of Genome Resources)	Chr8			XP_009302401 (RefSeq)
	mhc2d8.46a	ZDB-GENE-081105-52 (Zebrafish Model Organism Database) 571282 (Entrez Gene) mhc2d8.46a (Alliance of Genome Resources)	Chr8			XP_699949 (RefSeq)
	mhc2dga	ZDB-GENE-030616-505 (Zebrafish Model Organism Database) 368614 (Entrez Gene) mhc2dga (Alliance of Genome Resources)	Chr8			NP_001007206 (RefSeq) NM_001007205 (RefSeq)
	si:busm1-194e12.8	ZDB-GENE-030616-323 (Zebrafish Model Organism Database) 368816 (Entrez Gene) si:busm1-194e12.8 (Alliance of Genome Resources)	Chr8			NP_001007430 (RefSeq) NM_001007429 (RefSeq)
	zgc:123107	ZDB-GENE-051113-192 (Zebrafish Model Organism Database) 641415 (Entrez Gene) zgc:123107 (Alliance of Genome Resources)	Chr4			NP_001077290 (RefSeq) NM_001037404 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.