Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	HBB	HGNC:4827 (HGNC) 3043 (Entrez Gene) 141900 (OMIM) HBB (Alliance of Genome Resources)	Chr11 p15.4	Chr11:5225464-5229395 (-) GRCh38	acute chest syndrome alpha thalassemia autosomal dominant beta thalassemia beta thalassemia congenital hemolytic anemia delta beta-thalassemia familial erythrocytosis 6 Heinz body anemia hemoglobin C disease hemoglobinopathy malaria polycythemia sickle cell anemia sickle cell disease	P68871 (UniProt | EBI) NM_000518 (RefSeq)
	HBD	HGNC:4829 (HGNC) 3045 (Entrez Gene) 142000 (OMIM) HBD (Alliance of Genome Resources)	Chr11 p15.4	Chr11:5232678-5243657 (-) GRCh38		P02042 (UniProt | EBI) NM_000519 (RefSeq)
mouse	Hbb-bh2	MGI:96025 (MGI) 436003 (Entrez Gene) Gene Tree Hbb-bh2 (Alliance of Genome Resources)	Chr7 54.85 cM	Chr7:103488331-103489727 (-) GRCm39		ENSMUSG00000078621 (Ensembl Gene Model) ENSMUSP00000102479 (Ensembl) ENSMUST00000106866 (Ensembl)
zebrafish	ba1l	ZDB-GENE-040901-4 (Zebrafish Model Organism Database) 504174 (Entrez Gene) ba1l (Alliance of Genome Resources)	Chr3			NP_001013045 (RefSeq) NM_001013027 (RefSeq)
	hbba1	ZDB-GENE-990415-18 (Zebrafish Model Organism Database) 30216 (Entrez Gene) hbba1 (Alliance of Genome Resources)	Chr3			Q90485 (UniProt | EBI) NM_131020 (RefSeq)
	hbba2	ZDB-GENE-040801-164 (Zebrafish Model Organism Database) 445037 (Entrez Gene) hbba2 (Alliance of Genome Resources)	Chr3			NP_001003431 (RefSeq) NM_001003431 (RefSeq)
	hbbe1.1	ZDB-GENE-030616-7 (Zebrafish Model Organism Database) 81538 (Entrez Gene) hbbe1.1 (Alliance of Genome Resources)	Chr3			NP_932339 (RefSeq) NM_198073 (RefSeq)
	hbbe1.2	ZDB-GENE-090501-3 (Zebrafish Model Organism Database) 793447 (Entrez Gene) hbbe1.2 (Alliance of Genome Resources)	Chr3			NP_001096600 (RefSeq) NM_001103130 (RefSeq)
	hbbe1.3	ZDB-GENE-131120-128 (Zebrafish Model Organism Database) 573653 (Entrez Gene) hbbe1.3 (Alliance of Genome Resources)	Chr3			NP_001352192 (RefSeq) NM_001365263 (RefSeq)
	hbbe2	ZDB-GENE-040702-1 (Zebrafish Model Organism Database) 405772 (Entrez Gene) hbbe2 (Alliance of Genome Resources)	Chr12			NP_998011 (RefSeq) NM_212846 (RefSeq)
	hbbe3	ZDB-GENE-980526-287 (Zebrafish Model Organism Database) 30596 (Entrez Gene) hbbe3 (Alliance of Genome Resources)	Chr12			NP_001015058 (RefSeq) NM_001015058 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.