Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	APC	HGNC:583 (HGNC) 324 (Entrez Gene) 611731 (OMIM) APC (Alliance of Genome Resources)	Chr5 q22.2	Chr5:112707498-112846239 (+) GRCh38	acinar cell carcinoma adenocarcinoma adenoma cholangiocarcinoma colorectal cancer endometrial cancer endometrial carcinoma familial adenomatous polyposis 1 gallbladder cancer hepatocellular carcinoma hereditary desmoid disease medulloblastoma pancreatic cancer prostate cancer renal cell carcinoma stomach cancer transitional cell carcinoma	P25054 (UniProt | EBI) NM_001354905 (RefSeq)
mouse	Apc	MGI:88039 (MGI) 11789 (Entrez Gene) Gene Tree Apc (Alliance of Genome Resources)	Chr18 18.53 cM	Chr18:34353977-34455605 (+) GRCm39	breast cancer colorectal cancer familial adenomatous polyposis hepatocellular carcinoma ovarian cancer prostate cancer	ENSMUSG00000005871 (Ensembl Gene Model) ENSMUSP00000078337 (Ensembl) ENSMUST00000079362 (Ensembl)
rat	Apc	RGD:2123 (Rat Genome Database) 24205 (Entrez Gene) Apc (Alliance of Genome Resources)	Chr18 p12			P70478 (UniProt | EBI) NM_012499 (RefSeq)
zebrafish	apc	ZDB-GENE-031112-7 (Zebrafish Model Organism Database) 386762 (Entrez Gene) apc (Alliance of Genome Resources)	Chr10			NP_001137312 (RefSeq) NM_001143840 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.