Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SHH	HGNC:10848 (HGNC) 6469 (Entrez Gene) 600725 (OMIM) SHH (Alliance of Genome Resources)	Chr7 q36.3	Chr7:155799980-155812463 (-) GRCh38	basal cell carcinoma Hirschsprung's disease holoprosencephaly holoprosencephaly 3 hypoplastic or aplastic tibia with polydactyly middle cerebral artery infarction polydactyly solitary median maxillary central incisor syndactyly type 4	Q15465 (UniProt | EBI) NM_001310462 (RefSeq)
mouse	Shh	MGI:98297 (MGI) 20423 (Entrez Gene) Gene Tree Shh (Alliance of Genome Resources)	Chr5 14.39 cM	Chr5:28661838-28672099 (-) GRCm39	holoprosencephaly 3 nevoid basal cell carcinoma syndrome	20423 (NCBI Gene Model) Q62226 (UniProt | EBI) NM_009170 (RefSeq)
rat	Shh	RGD:3673 (Rat Genome Database) 29499 (Entrez Gene) Shh (Alliance of Genome Resources)	Chr4 q11			Q63673 (UniProt | EBI) NM_017221 (RefSeq)
zebrafish	shha	ZDB-GENE-980526-166 (Zebrafish Model Organism Database) 30269 (Entrez Gene) shha (Alliance of Genome Resources)	Chr7			Q92008 (UniProt | EBI) NM_131063 (RefSeq)
	shhb	ZDB-GENE-980526-41 (Zebrafish Model Organism Database) 30444 (Entrez Gene) shhb (Alliance of Genome Resources)	Chr2			Q90419 (UniProt | EBI) NM_131199 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.