Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	HTRA1	HGNC:9476 (HGNC) 5654 (Entrez Gene) 602194 (OMIM) HTRA1 (Alliance of Genome Resources)	Chr10 q26.13	Chr10:122458551-122514907 (+) GRCh38	age related macular degeneration age related macular degeneration 7 CADASIL CADASIL 2 colon cancer esophagus squamous cell carcinoma hypertension Kuhnt-Junius degeneration lung adenocarcinoma patterned macular dystrophy vitelliform macular dystrophy	Q92743 (UniProt | EBI) NM_002775 (RefSeq)
mouse	Htra1	MGI:1929076 (MGI) 56213 (Entrez Gene) Gene Tree Htra1 (Alliance of Genome Resources)	Chr7 73.2 cM	Chr7:130537933-130587388 (+) GRCm39		56213 (NCBI Gene Model) Q9R118 (UniProt | EBI) NM_019564 (RefSeq)
rat	Htra1	RGD:69235 (Rat Genome Database) 65164 (Entrez Gene) Htra1 (Alliance of Genome Resources)	Chr1 q41			Q9QZK5 (UniProt | EBI) NM_031721 (RefSeq)
zebrafish	htra1a	ZDB-GENE-040704-64 (Zebrafish Model Organism Database) 431766 (Entrez Gene) htra1a (Alliance of Genome Resources)	Chr17			Q6GMI0 (UniProt | EBI) NM_001002219 (RefSeq)
	htra1b	ZDB-GENE-080219-7 (Zebrafish Model Organism Database) 565082 (Entrez Gene) htra1b (Alliance of Genome Resources)	Chr12			A9JRB3 (UniProt | EBI) NM_001111182 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.