Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	PNPLA3	HGNC:18590 (HGNC) 80339 (Entrez Gene) 609567 (OMIM) PNPLA3 (Alliance of Genome Resources)	Chr22 q13.31	Chr22:43923792-43964488 (+) GRCh38	coronary artery disease hepatocellular carcinoma liver cirrhosis metabolic dysfunction-associated steatotic liver disease steatotic liver disease type 2 diabetes mellitus	Q9NST1 (UniProt | EBI) NM_025225 (RefSeq)
mouse	Pnpla3	MGI:2151796 (MGI) 116939 (Entrez Gene) Gene Tree Pnpla3 (Alliance of Genome Resources)	Chr15 39.78 cM	Chr15:84052038-84071437 (+) GRCm39	metabolic dysfunction-associated steatotic liver disease	ENSMUSG00000041653 (Ensembl Gene Model) ENSMUSP00000043826 (Ensembl) ENSMUST00000045289 (Ensembl)
rat	Pnpla3	RGD:1595843 (Rat Genome Database) 362972 (Entrez Gene) Pnpla3 (Alliance of Genome Resources)	Chr7 q34			NP_001269253 (RefSeq) NM_001282324 (RefSeq)
zebrafish	pnpla3	ZDB-GENE-040718-27 (Zebrafish Model Organism Database) 436610 (Entrez Gene) pnpla3 (Alliance of Genome Resources)	Chr4			NP_001002338 (RefSeq) NM_001002338 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.