Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	IRF4	HGNC:6119 (HGNC) 3662 (Entrez Gene) 601900 (OMIM) IRF4 (Alliance of Genome Resources)	Chr6 p25.3	Chr6:391739-411443 (+) GRCh38	acute lymphoblastic leukemia anaplastic large cell lymphoma chronic lymphocytic leukemia multiple myeloma peripheral T-cell lymphoma pigmentation disease	Q15306 (UniProt | EBI) NM_002460 (RefSeq)
mouse	Irf4	MGI:1096873 (MGI) 16364 (Entrez Gene) Gene Tree Irf4 (Alliance of Genome Resources)	Chr13 13.28 cM	Chr13:30933209-30950959 (+) GRCm39		ENSMUSG00000021356 (Ensembl Gene Model) ENSMUSP00000021784 (Ensembl) ENSMUST00000021784 (Ensembl)
rat	Irf4	RGD:1308050 (Rat Genome Database) 291100 (Entrez Gene) Irf4 (Alliance of Genome Resources)	Chr17 p12			NP_001099578 (RefSeq) NM_001106108 (RefSeq)
zebrafish	irf4a	ZDB-GENE-070912-330 (Zebrafish Model Organism Database) 100002070 (Entrez Gene) irf4a (Alliance of Genome Resources)	Chr2			NP_001116182 (RefSeq) NM_001122710 (RefSeq)
	irf4b	ZDB-GENE-041001-131 (Zebrafish Model Organism Database) 569263 (Entrez Gene) irf4b (Alliance of Genome Resources)	Chr20			XP_009301432 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.