Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	IRF1	HGNC:6116 (HGNC) 3659 (Entrez Gene) 147575 (OMIM) IRF1 (Alliance of Genome Resources)	Chr5 q31.1	Chr5:132440440-132508719 (-) GRCh38	asthma gastric adenocarcinoma lung cancer lung non-small cell carcinoma primary immunodeficiency disease smallpox stomach cancer	P10914 (UniProt | EBI) NM_001354924 (RefSeq)
mouse	Irf1	MGI:96590 (MGI) 16362 (Entrez Gene) Gene Tree Irf1 (Alliance of Genome Resources)	Chr11 32.0 cM	Chr11:53660841-53669200 (+) GRCm39		16362 (NCBI Gene Model) P15314 (UniProt | EBI) NM_008390 (RefSeq)
rat	Irf1	RGD:2920 (Rat Genome Database) 24508 (Entrez Gene) Irf1 (Alliance of Genome Resources)	Chr10 q22			P23570 (UniProt | EBI) NM_012591 (RefSeq)
zebrafish	irf1a	ZDB-GENE-060421-4031 (Zebrafish Model Organism Database) 678604 (Entrez Gene) irf1a (Alliance of Genome Resources)	Chr13			NP_001035442 (RefSeq) NM_001040352 (RefSeq)
	irf1b	ZDB-GENE-041114-13 (Zebrafish Model Organism Database) 792160 (Entrez Gene) irf1b (Alliance of Genome Resources)	Chr21			NP_991310 (RefSeq) NM_205747 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.