LEP Vertebrate HGNC

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Vertebrate Homology

Source

Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
- human
- mouse
- rat
- zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences select all deselect all Go
human	LEP	HGNC:6553 (HGNC) 3952 (Entrez Gene) 164160 (OMIM) LEP (Alliance of Genome Resources)	Chr7 q32.1	Chr7:128241278-128257629 (+) GRCh38	adult respiratory distress syndrome alcohol dependence alcoholic liver cirrhosis chronic obstructive pulmonary disease congenital leptin deficiency hepatocellular carcinoma hypertension osteoporosis rhinitis type 2 diabetes mellitus	P41159 (UniProt \| EBI) NM_000230 (RefSeq)
mouse	Lep	MGI:104663 (MGI) 16846 (Entrez Gene) Gene Tree Lep (Alliance of Genome Resources)	Chr6 12.3 cM	Chr6:29060220-29073875 (+) GRCm39	abdominal obesity-metabolic syndrome abdominal obesity-metabolic syndrome 1 metabolic dysfunction-associated steatotic liver disease obesity steatotic liver disease type 2 diabetes mellitus	16846 (NCBI Gene Model) P41160 (UniProt \| EBI) NM_008493 (RefSeq)
rat	Lep	RGD:3000 (Rat Genome Database) 25608 (Entrez Gene) Lep (Alliance of Genome Resources)	Chr4 q22			P50596 (UniProt \| EBI) NM_013076 (RefSeq)
zebrafish	lepa	ZDB-GENE-081001-1 (Zebrafish Model Organism Database) 100150233 (Entrez Gene) lepa (Alliance of Genome Resources)	Chr18			NP_001122048 (RefSeq) NM_001128576 (RefSeq)
zebrafish	lepb	ZDB-GENE-041210-183 (Zebrafish Model Organism Database) 564348 (Entrez Gene) lepb (Alliance of Genome Resources)	Chr4			NP_001025357 (RefSeq) NM_001030186 (RefSeq)