Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	PITX3	HGNC:9006 (HGNC) 5309 (Entrez Gene) 602669 (OMIM) PITX3 (Alliance of Genome Resources)	Chr10 q24.32	Chr10:102230189-102241512 (-) GRCh38	anterior segment dysgenesis anterior segment dysgenesis 1 cataract cataract 11 multiple types cataract 9 multiple types	O75364 (UniProt | EBI) NM_005029 (RefSeq)
mouse	Pitx3	MGI:1100498 (MGI) 18742 (Entrez Gene) Gene Tree Pitx3 (Alliance of Genome Resources)	Chr19 38.75 cM	Chr19:46124124-46136765 (-) GRCm39	anterior segment dysgenesis Parkinson's disease	ENSMUSG00000025229 (Ensembl Gene Model) ENSMUSP00000026259 (Ensembl) ENSMUST00000026259 (Ensembl)
rat	Pitx3	RGD:3332 (Rat Genome Database) 29609 (Entrez Gene) Pitx3 (Alliance of Genome Resources)	Chr1 q54			P81062 (UniProt | EBI) NM_019247 (RefSeq)
zebrafish	pitx3	ZDB-GENE-041229-4 (Zebrafish Model Organism Database) 402974 (Entrez Gene) pitx3 (Alliance of Genome Resources)	Chr13			Q6QU75 (UniProt | EBI) NM_205675 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.