Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	LTA	HGNC:6709 (HGNC) 4049 (Entrez Gene) 153440 (OMIM) LTA (Alliance of Genome Resources)	Chr6 p21.33	Chr6:31560610-31574324 (+) GRCh38	adult respiratory distress syndrome allergic disease asthma breast cancer carotid artery disease cerebral infarction chorioamnionitis coronary artery disease cystic fibrosis dermatitis herpetiformis diabetic retinopathy endometrial cancer erythema nodosum Graves' disease high grade glioma hyperinsulinism leprosy mucocutaneous leishmaniasis myocardial infarction neovascular inflammatory vitreoretinopathy psoriasis psoriatic arthritis pulmonary sarcoidosis pulmonary tuberculosis pustulosis of palm and sole sinusitis Sjogren's syndrome systemic scleroderma type 1 diabetes mellitus type 2 diabetes mellitus typhoid fever visceral leishmaniasis	P01374 (UniProt | EBI) NM_001159740 (RefSeq)
mouse	Lta	MGI:104797 (MGI) 16992 (Entrez Gene) Gene Tree Lta (Alliance of Genome Resources)	Chr17 18.59 cM	Chr17:35422141-35424327 (-) GRCm39		ENSMUSG00000024402 (Ensembl Gene Model) ENSMUSP00000025266 (Ensembl) ENSMUST00000025266 (Ensembl)
rat	Lta	RGD:3020 (Rat Genome Database) 25008 (Entrez Gene) Lta (Alliance of Genome Resources)	Chr20 p12			Q06332 (UniProt | EBI) NM_080769 (RefSeq)
zebrafish	lta	ZDB-GENE-050601-3 (Zebrafish Model Organism Database) 554305 (Entrez Gene) lta (Alliance of Genome Resources)	Chr15			NP_001019992 (RefSeq) NM_001024821 (RefSeq)
	tnfa	ZDB-GENE-050317-1 (Zebrafish Model Organism Database) 405785 (Entrez Gene) tnfa (Alliance of Genome Resources)	Chr19			NP_998024 (RefSeq) NM_212859 (RefSeq)
	tnfb	ZDB-GENE-050601-2 (Zebrafish Model Organism Database) 554167 (Entrez Gene) tnfb (Alliance of Genome Resources)	Chr15			NP_001019618 (RefSeq) NM_001024447 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.