Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	TNF	HGNC:11892 (HGNC) 7124 (Entrez Gene) 191160 (OMIM) TNF (Alliance of Genome Resources)	Chr6 p21.33	Chr6:31575565-31578336 (+) GRCh38	acne adult respiratory distress syndrome Alzheimer's disease anterior uveitis aplastic anemia asthma atopic dermatitis bacterial pneumonia Behcet's disease beta thalassemia breast adenocarcinoma breast cancer bronchopulmonary dysplasia cerebral infarction cervical cancer chorioamnionitis chronic obstructive pulmonary disease coronary artery disease coronary restenosis cystic fibrosis dermatitis dermatitis herpetiformis diabetic angiopathy diabetic retinopathy erythema nodosum esophagitis extrinsic allergic alveolitis farmer's lung Gaucher's disease Graves' disease Graves ophthalmopathy hemochromatosis hepatitis B hepatocellular carcinoma hidradenitis suppurativa high grade glioma hypertension hypochromic microcytic anemia intermediate uveitis iron deficiency anemia Kawasaki disease leprosy liver disease low tension glaucoma lung non-small cell carcinoma malaria migraine migraine without aura mucocutaneous leishmaniasis multiple myeloma multiple sclerosis neutropenia obstructive sleep apnea open-angle glaucoma paracoccidioidomycosis pre-eclampsia primary open angle glaucoma prostate cancer psoriasis psoriatic arthritis pulmonary fibrosis pulmonary sarcoidosis pulmonary tuberculosis pustulosis of palm and sole renal cell carcinoma rheumatoid arthritis rhinitis schizophrenia scleritis sensorineural hearing loss silicosis Sjogren's syndrome skin disease systemic lupus erythematosus thrombocytopenia trachoma type 1 diabetes mellitus typhoid fever uveitis vascular dementia visceral leishmaniasis visual epilepsy	P01375 (UniProt | EBI) NM_000594 (RefSeq)
mouse	Tnf	MGI:104798 (MGI) 21926 (Entrez Gene) Gene Tree Tnf (Alliance of Genome Resources)	Chr17 18.59 cM	Chr17:35418357-35420983 (-) GRCm39	aortic valve stenosis congestive heart failure dilated cardiomyopathy heart valve disease idiopathic pulmonary fibrosis inflammatory bowel disease multiple sclerosis rheumatoid arthritis spondyloarthropathy	ENSMUSG00000024401 (Ensembl Gene Model) ENSMUSP00000025263 (Ensembl) ENSMUST00000025263 (Ensembl)
rat	Tnf	RGD:3876 (Rat Genome Database) 24835 (Entrez Gene) Tnf (Alliance of Genome Resources)	Chr20 p12			P16599 (UniProt | EBI) NM_012675 (RefSeq)
zebrafish	tnfa	ZDB-GENE-050317-1 (Zebrafish Model Organism Database) 405785 (Entrez Gene) tnfa (Alliance of Genome Resources)	Chr19			NP_998024 (RefSeq) NM_212859 (RefSeq)
	tnfb	ZDB-GENE-050601-2 (Zebrafish Model Organism Database) 554167 (Entrez Gene) tnfb (Alliance of Genome Resources)	Chr15			NP_001019618 (RefSeq) NM_001024447 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.