Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	ABCA4	HGNC:34 (HGNC) 24 (Entrez Gene) 601691 (OMIM) ABCA4 (Alliance of Genome Resources)	Chr1 p22.1	Chr1:93992834-94121148 (-) GRCh38	age related macular degeneration 2 cone-rod dystrophy 3 fundus dystrophy macular degeneration retinal degeneration retinitis pigmentosa retinitis pigmentosa 19	P78363 (UniProt | EBI) NM_000350 (RefSeq)
mouse	Abca4	MGI:109424 (MGI) 11304 (Entrez Gene) Gene Tree Abca4 (Alliance of Genome Resources)	Chr3 52.94 cM	Chr3:121838092-121973772 (+) GRCm39	cone-rod dystrophy 3 retinitis pigmentosa 19 Stargardt disease	ENSMUSG00000028125 (Ensembl Gene Model) ENSMUSP00000013995 (Ensembl) ENSMUST00000013995 (Ensembl)
rat	Abca4	RGD:1309445 (Rat Genome Database) 310836 (Entrez Gene) Abca4 (Alliance of Genome Resources)	Chr2 q42			NP_001101191 (RefSeq) NM_001107721 (RefSeq)
zebrafish	abca4a	ZDB-GENE-050517-3 (Zebrafish Model Organism Database) 798993 (Entrez Gene) abca4a (Alliance of Genome Resources)	Chr24			NP_001002206 (RefSeq) NM_001002206 (RefSeq)
	abca4b	ZDB-GENE-050517-4 (Zebrafish Model Organism Database) 555506 (Entrez Gene) abca4b (Alliance of Genome Resources)	Chr2			XP_005163385 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.