Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SCN4A	HGNC:10591 (HGNC) 6329 (Entrez Gene) 603967 (OMIM) SCN4A (Alliance of Genome Resources)	Chr17 q23.3	Chr17:63938554-63972918 (-) GRCh38	congenital myasthenic syndrome 16 congenital myopathy 22A congenital myopathy 22B hyperkalemic periodic paralysis paramyotonia congenita of Von Eulenburg	P35499 (UniProt | EBI) NM_000334 (RefSeq)
mouse	Scn4a	MGI:98250 (MGI) 110880 (Entrez Gene) Gene Tree Scn4a (Alliance of Genome Resources)	Chr11 68.91 cM	Chr11:106209418-106244114 (-) GRCm39	hyperkalemic periodic paralysis hypokalemic periodic paralysis	ENSMUSG00000001027 (Ensembl Gene Model) ENSMUSP00000021056 (Ensembl) ENSMUST00000021056 (Ensembl)
rat	Scn4a	RGD:3636 (Rat Genome Database) 25722 (Entrez Gene) Scn4a (Alliance of Genome Resources)	Chr10 q32.1			P15390 (UniProt | EBI) NM_013178 (RefSeq)
zebrafish	scn4aa	ZDB-GENE-051201-2 (Zebrafish Model Organism Database) 572442 (Entrez Gene) scn4aa (Alliance of Genome Resources)	Chr12			Q2XVR3 (UniProt | EBI) NM_001039825 (RefSeq)
	scn4ab	ZDB-GENE-051201-1 (Zebrafish Model Organism Database) 564977 (Entrez Gene) scn4ab (Alliance of Genome Resources)	Chr3			Q20JQ7 (UniProt | EBI) NM_001045065 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.