Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	VHL	HGNC:12687 (HGNC) 7428 (Entrez Gene) 608537 (OMIM) VHL (Alliance of Genome Resources)	Chr3 p25.3	Chr3:10141778-10153667 (+) GRCh38	familial erythrocytosis 2 hypertension pancreatic cancer pancreatic ductal carcinoma pheochromocytoma polycythemia renal cell carcinoma von Hippel-Lindau disease	P40337 (UniProt | EBI) NM_198156 (RefSeq)
	VHLL	HGNC:30666 (HGNC) 391104 (Entrez Gene) 619650 (OMIM) VHLL (Alliance of Genome Resources)	Chr1 q22	Chr1:156298624-156299307 (-) GRCh38		Q6RSH7 (UniProt | EBI) NM_001004319 (RefSeq)
mouse	Vhl	MGI:103223 (MGI) 22346 (Entrez Gene) Gene Tree Vhl (Alliance of Genome Resources)	Chr6 52.81 cM	Chr6:113600955-113608595 (+) GRCm39	familial erythrocytosis 2 sudden infant death syndrome von Hippel-Lindau disease	22346 (NCBI Gene Model) P40338 (UniProt | EBI) NM_009507 (RefSeq)
rat	Vhl	RGD:3960 (Rat Genome Database) 24874 (Entrez Gene) Vhl (Alliance of Genome Resources)	Chr4 q42			Q64259 (UniProt | EBI) NM_052801 (RefSeq)
zebrafish	vhl	ZDB-GENE-070112-1042 (Zebrafish Model Organism Database) 791202 (Entrez Gene) vhl (Alliance of Genome Resources)	Chr6			NP_001074153 (RefSeq) NM_001080684 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.