Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	GCH1	HGNC:4193 (HGNC) 2643 (Entrez Gene) 600225 (OMIM) GCH1 (Alliance of Genome Resources)	Chr14 q22.2	Chr14:54842008-54902826 (-) GRCh38	BH4-deficient hyperphenylalaninemia B bipolar disorder cerebral infarction diabetic angiopathy dopa-responsive dystonia dystonia hypertension Parkinsonism sickle cell anemia type 2 diabetes mellitus	P30793 (UniProt | EBI) NM_001024024 (RefSeq)
mouse	Gch1	MGI:95675 (MGI) 14528 (Entrez Gene) Gene Tree Gch1 (Alliance of Genome Resources)	Chr14 24.6 cM	Chr14:47391352-47426870 (-) GRCm39	BH4-deficient hyperphenylalaninemia B	14528 (NCBI Gene Model) Q05915 (UniProt | EBI) NM_008102 (RefSeq)
rat	Gch1	RGD:61992 (Rat Genome Database) 29244 (Entrez Gene) Gch1 (Alliance of Genome Resources)	Chr15 p14			P22288 (UniProt | EBI) NM_024356 (RefSeq)
zebrafish	gch1	ZDB-GENE-070720-5 (Zebrafish Model Organism Database) 100192219 (Entrez Gene) gch1 (Alliance of Genome Resources)	Chr17			NP_001129727 (RefSeq) NM_001136255 (RefSeq)
	gch2	ZDB-GENE-001205-3 (Zebrafish Model Organism Database) 64263 (Entrez Gene) gch2 (Alliance of Genome Resources)	Chr12			NP_571742 (RefSeq) NM_131667 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.