Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SERPINE1	HGNC:8583 (HGNC) 5054 (Entrez Gene) 173360 (OMIM) SERPINE1 (Alliance of Genome Resources)	Chr7 q22.1	Chr7:101127104-101139247 (+) GRCh38	alcoholic liver cirrhosis amyloidosis asthma coronary artery disease diabetic angiopathy diabetic retinopathy familial Mediterranean fever glomerulonephritis Graves' disease interstitial lung disease ischemic colitis liver cirrhosis myocardial infarction pleurisy pneumonia portal vein thrombosis proliferative diabetic retinopathy pulmonary fibrosis pulmonary hypertension retinal vein occlusion retinopathy of prematurity rhinitis thrombosis toxic shock syndrome urinary bladder cancer uveal melanoma	P05121 (UniProt | EBI) NM_001386457 (RefSeq)
mouse	Serpine1	MGI:97608 (MGI) 18787 (Entrez Gene) Gene Tree Serpine1 (Alliance of Genome Resources)	Chr5 76.16 cM	Chr5:137090358-137101122 (-) GRCm39	Coronavirus infectious disease	ENSMUSG00000037411 (Ensembl Gene Model) ENSMUSP00000039586 (Ensembl) ENSMUST00000041388 (Ensembl)
rat	Serpine1	RGD:3249 (Rat Genome Database) 24617 (Entrez Gene) Serpine1 (Alliance of Genome Resources)	Chr12 q12			P20961 (UniProt | EBI) NM_012620 (RefSeq)
zebrafish	serpine1	ZDB-GENE-070912-60 (Zebrafish Model Organism Database) 100136840 (Entrez Gene) serpine1 (Alliance of Genome Resources)	Chr7			NP_001108031 (RefSeq) NM_001114559 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.