Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	ABCB4	HGNC:45 (HGNC) 5244 (Entrez Gene) 171060 (OMIM) ABCB4 (Alliance of Genome Resources)	Chr7 q21.12	Chr7:87365896-87480435 (-) GRCh38	cholestasis intrahepatic cholestasis intrahepatic cholestasis of pregnancy 3 liver cirrhosis primary biliary cholangitis progressive familial intrahepatic cholestasis 3	P21439 (UniProt | EBI) NM_018849 (RefSeq)
mouse	Abcb4	MGI:97569 (MGI) 18670 (Entrez Gene) Gene Tree Abcb4 (Alliance of Genome Resources)	Chr5 3.43 cM	Chr5:8943717-9009231 (+) GRCm39	cholecystitis cholestasis hepatocellular carcinoma intrahepatic cholestasis primary sclerosing cholangitis	ENSMUSG00000042476 (Ensembl Gene Model) ENSMUSP00000003717 (Ensembl) ENSMUST00000003717 (Ensembl)
rat	Abcb4	RGD:620248 (Rat Genome Database) 24891 (Entrez Gene) Abcb4 (Alliance of Genome Resources)	Chr4 q12			Q08201 (UniProt | EBI) NM_012690 (RefSeq)
zebrafish	abcb4	ZDB-GENE-080204-52 (Zebrafish Model Organism Database) 100136865 (Entrez Gene) abcb4 (Alliance of Genome Resources)	Chr16			NP_001108055 (RefSeq) NM_001114583 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.