Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	TSHR	HGNC:12373 (HGNC) 7253 (Entrez Gene) 603372 (OMIM) TSHR (Alliance of Genome Resources)	Chr14 q31.1	Chr14:80954989-81146306 (+) GRCh38	cardiomyopathy familial gestational hyperthyroidism Graves' disease Graves ophthalmopathy mitral valve prolapse nonautoimmune hyperthyroidism	P16473 (UniProt | EBI) NM_001142626 (RefSeq)
mouse	Tshr	MGI:98849 (MGI) 22095 (Entrez Gene) Gene Tree Tshr (Alliance of Genome Resources)	Chr12 44.51 cM	Chr12:91367767-91507283 (+) GRCm39	congenital hypothyroidism	22095 (NCBI Gene Model) P47750 (UniProt | EBI) NM_011648 (RefSeq)
rat	Tshr	RGD:3911 (Rat Genome Database) 25360 (Entrez Gene) Tshr (Alliance of Genome Resources)	Chr6 q31			P21463 (UniProt | EBI) NM_012888 (RefSeq)
zebrafish	tshr	ZDB-GENE-110524-4 (Zebrafish Model Organism Database) 560609 (Entrez Gene) tshr (Alliance of Genome Resources)	Chr20			NP_001139235 (RefSeq) NM_001145763 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.