Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	IL6	HGNC:6018 (HGNC) 3569 (Entrez Gene) 147620 (OMIM) IL6 (Alliance of Genome Resources)	Chr7 p15.3	Chr7:22725884-22732002 (+) GRCh38	acute myeloid leukemia aggressive periodontitis arteriovenous malformations of the brain breast cancer celiac disease colorectal cancer Crohn's disease depressive disorder diabetes mellitus diabetic retinopathy dry eye syndrome gestational diabetes glucosephosphate dehydrogenase deficiency Graves' disease hepatitis B hepatitis C hepatocellular carcinoma Hodgkin's lymphoma Huntington's disease hyperglycemia hyperinsulinism hypertension intracranial aneurysm Kaposi's sarcoma keratitis lymphoplasmacytic lymphoma major depressive disorder metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease multiple sclerosis obesity otitis media periodontal disease periodontitis peripheral vascular disease prediabetes syndrome quadriplegia rectum cancer retinal artery occlusion Sjogren's syndrome stomach cancer type 1 diabetes mellitus type 2 diabetes mellitus uveitis	P05231 (UniProt | EBI) NM_000600 (RefSeq)
mouse	Il6	MGI:96559 (MGI) 16193 (Entrez Gene) Gene Tree Il6 (Alliance of Genome Resources)	Chr5 15.7 cM	Chr5:30218112-30224973 (+) GRCm39		16193 (NCBI Gene Model) P08505 (UniProt | EBI) NM_031168 (RefSeq)
rat	Il6	RGD:2901 (Rat Genome Database) 24498 (Entrez Gene) Il6 (Alliance of Genome Resources)	Chr4 q11			P20607 (UniProt | EBI) NM_012589 (RefSeq)
zebrafish	il6	ZDB-GENE-120509-1 (Zebrafish Model Organism Database) 100885851 (Entrez Gene) il6 (Alliance of Genome Resources)	Chr19			NP_001248378 (RefSeq) NM_001261449 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.