Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	ISL1	HGNC:6132 (HGNC) 3670 (Entrez Gene) 600366 (OMIM) ISL1 (Alliance of Genome Resources)	Chr5 q11.1	Chr5:51383448-51394730 (+) GRCh38	atrial fibrillation atrial heart septal defect congenital heart disease dilated cardiomyopathy double outlet right ventricle myocardial infarction type 1 diabetes mellitus type 2 diabetes mellitus ventricular septal defect	P61371 (UniProt | EBI) NM_002202 (RefSeq)
mouse	Isl1	MGI:101791 (MGI) 16392 (Entrez Gene) Gene Tree Isl1 (Alliance of Genome Resources)	Chr13 64.87 cM	Chr13:116434817-116446225 (-) GRCm39		ENSMUSG00000042258 (Ensembl Gene Model) ENSMUSP00000044879 (Ensembl) ENSMUST00000036060 (Ensembl)
rat	Isl1	RGD:61957 (Rat Genome Database) 64444 (Entrez Gene) Isl1 (Alliance of Genome Resources)	Chr2 q14			P61374 (UniProt | EBI) NM_017339 (RefSeq)
zebrafish	isl1a	ZDB-GENE-980526-112 (Zebrafish Model Organism Database) 30147 (Entrez Gene) isl1a (Alliance of Genome Resources)	Chr5			P53405 (UniProt | EBI) NM_130962 (RefSeq)
	isl1b	ZDB-GENE-040624-1 (Zebrafish Model Organism Database) 415131 (Entrez Gene) isl1b (Alliance of Genome Resources)	Chr10			NP_001002043 (RefSeq) NM_001002043 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.