Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	NKX2-5	HGNC:2488 (HGNC) 1482 (Entrez Gene) 600584 (OMIM) NKX2-5 (Alliance of Genome Resources)	Chr5 q35.1	Chr5:173232109-173235311 (-) GRCh38	aortic valve disease 2 atrial heart septal defect atrial heart septal defect 7 atrioventricular block congenital heart disease congenital nongoitrous hypothyroidism 5 heart septal defect hypoplastic left heart syndrome tetralogy of Fallot ventricular septal defect	P52952 (UniProt | EBI) NM_001166175 (RefSeq)
mouse	Nkx2-5	MGI:97350 (MGI) 18091 (Entrez Gene) Gene Tree Nkx2-5 (Alliance of Genome Resources)	Chr17 13.6 cM	Chr17:27057638-27063962 (-) GRCm39	atrial heart septal defect 7 congenital heart disease hypoplastic left heart syndrome tetralogy of Fallot	18091 (NCBI Gene Model) P42582 (UniProt | EBI) NM_008700 (RefSeq)
rat	Nkx2-5	RGD:620520 (Rat Genome Database) 114109 (Entrez Gene) Nkx2-5 (Alliance of Genome Resources)	Chr10 q12			O35767 (UniProt | EBI) NM_053651 (RefSeq)
zebrafish	nkx2.5	ZDB-GENE-980526-321 (Zebrafish Model Organism Database) 30696 (Entrez Gene) nkx2.5 (Alliance of Genome Resources)	Chr14			NP_571496 (RefSeq) NM_131421 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.